Polynucleotides DNA Healer

What are Polynucleotides?

A regenerative injectable gel made of filtered, ultra-purified DNA fractions (usually salmon-derived) that act as supreme biostimulators.

Derived from Salmon DNA (which has high biocompatibility with human DNA), this is a "healer" rather than a "booster."

How Do Polynucleotides Work?

They signal cellular receptors (CD39/CD40) to jumpstart repair, increase blood flow (angiogenesis), and calm inflammation. PN/PDRN Polynucleotides activate the Adenosine A2A receptors, triggering a powerful anti-inflammatory and wound-healing response. They utilise the "Salvage Pathway" of DNA synthesis to repair damaged cells. They hunt down free radicals (oxidative stress) and neutralise them while priming the skin for deep repair.

Treatment Applications?

Under-eye Hollowing & Dark Circles

Rosacea & Redness

Acne Scarring

Inflamed Skin

Hair Loss (Scalp)

Treatment Process

Sessions: 2–3 sessions, spaced 2–3 weeks apart.

Downtime: Moderate (swelling/bumps for 1–3 days).

Discomfort: Low, as we use the smallest and thinnest world’s needles for maximum comfort.

Polynucleotides & Skingevity?

They are working at the DNA/cellular signal level. Polynucleotides reduce Inflammaging (chronic inflammation that speeds up ageing). By improving micro-circulation and scavenging free radicals, they improve the Biological Quality of the skin tissue, not just its appearance.

Polynucleotides Advantages?

Randomised Controlled Trials on Rejuran Polynucleotides demonstrate:

Significant increase in dermal thickness and density.

Improvement in skin elasticity and hydration relative to non-crosslinked HA groups.

Faster healing of wounds and reduction in inflammatory markers.

It is the only injectable that can be safely used right up to the lash line and on injured skin. It doesn't just hydrate; it repairs the biological machinery of the skin cells.

We often pair them with energy devices to maximise the "healing signal" for faster recovery and better results. At Collagen Clinic London, we only use the highest-grade, filtered polynucleotides for maximum bio-compatibility.